BDBM496831 SARS-CoV-2 PLpro Inhibitor, 61

SMILES C[C@@H](NC(=O)c1cc(ccc1C)N(C)C1CNC1)c1nccc2ccccc12

InChI Key InChIKey=KDSVZTQWKOOLMW-MRXNPFEDSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 496831   

TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Illinois At Chicago

LigandPNGBDBM496831(SARS-CoV-2 PLpro Inhibitor, 61)
Affinity DataIC50:  5.60E+4nMAssay Description:The PLpro primary assay, which measures protease activity with the short peptide substrate Z-RLRGG-AMC (Bachem), was performed in black flat-bottom 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Illinois At Chicago

LigandPNGBDBM496831(SARS-CoV-2 PLpro Inhibitor, 61)
Affinity DataIC50:  5.60E+4nMAssay Description:Inhibition of SARS-CoV-2 PLproMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of Illinois At Chicago

LigandPNGBDBM496831(SARS-CoV-2 PLpro Inhibitor, 61)
Affinity DataKd:  1.96E+4nMAssay Description:The His-tagged SARS-CoV-2 PLpro enzyme was initially prepared in phosphate buffer and diluted to 50 ug/mL with 10 mM sodium acetate (pH 5.5) and immo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed