BDBM497007 US11001561, Compound 4::US11104675, Example 3::US11702392, Compound 4
SMILES Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC(C)(CN)CC1
InChI Key InChIKey=XVYAPWLPPUVJIR-UHFFFAOYSA-N
Data 3 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 497007
TargetTyrosine-protein phosphatase non-receptor type 11 [E76K](Homo sapiens (Human))
Navire Pharma
US Patent
Navire Pharma
US Patent
Affinity DataIC50: 310nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair