BDBM497077 US11001561, Compound 66a::US11702392, Compound 66a

SMILES Cc1nc(N2CCC3(Cc4ncccc4[C@H]3N)CC2)c(C)c(=O)n1-c1cccc(Cl)c1Cl

InChI Key InChIKey=PUAFKERZWLWHED-OAQYLSRUSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 497077   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50:  73nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50:  73nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76Z](Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50:  200nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11 [E76Z](Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50:  97nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM497077(US11001561, Compound 66a | US11702392, Compound 66...)
Affinity DataIC50:  48nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent