BDBM497089 US11001561, Compound 74b

SMILES Cc1nc(N2CCC3(Cc4ccccc4[C@@H]3N)CC2)c(C)c(=O)n1C1=CC=C[C@H](Cl)C1Cl

InChI Key InChIKey=LTJYHEMSWLQOBU-LLLPINGXSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497089   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM497089(US11001561, Compound 74b)
Affinity DataIC50:  26nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent