BDBM497527 2-methyl-2-[2-[6-[(1S,8R)-5-(2,6- difluorophenyl)-11,11-dimethyl-3,4- diazatricyclo[6.2.1.02,7]undeca-2(7),3,5- trien-1-yl]pyrazin-2-yl]oxazol-4- yl]propanenitrile::US11008312, Example 27

SMILES CC(C)(C#N)c1coc(n1)-c1cncc(n1)[C@@]12CC[C@@H](c3cc(nnc13)-c1c(F)cccc1F)C2(C)C

InChI Key InChIKey=QTJRQSKYLMBKDC-OLRZCDJHSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 497527   

TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM497527(2-methyl-2-[2-[6-[(1S,8R)-5-(2,6- difluorophenyl)-...)
Affinity DataIC50:  3.60nMAssay Description:50 mM HEPES buffer (pH 7.4); 150 mM NaCl; 1 mM DTT; 5 mM MgCl2; 0.01% BSA; 5% DMSO; 0.6 ug/mL RORc receptor; 6 nM 25-[3H]hydroxycholesterol. For NSB ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent