BDBM498075 (2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimid in-4-yl}-1-oxo-2,3- dihydro-1H-isoindol-2-yl)-N-[(1S,2S)- 1-(5-fluoro-6-methylpyridin-2-yl)-2- hydroxypropyl]propanamide::US11001575, Example 1045

SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ncc(cc2C1=O)-c1nc(Nc2cn(C)nn2)ncc1Cl

InChI Key InChIKey=YAUQBWCPDSHWNI-LRTDBIEQSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498075   

TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
Otsuka Pharmaceutical

US Patent
LigandPNGBDBM498075((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimid i...)
Affinity DataIC50:  1.70nMAssay Description:Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent