BDBM498126 US11013745, Compound E-Y42

SMILES Cc1cc(C(=O)N2CCC(=CC2)c2cnc(NCc3c4CCOc4ccc3F)n3cnnc23)n(C)n1

InChI Key InChIKey=PMNFISMZZAVMSE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498126   

TargetHistone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED [40-441]/Polycomb protein SUZ12(Homo sapiens (Human))
Shanghai Institute Of Material Medica, Chinese Academy Of Sciences

US Patent
LigandPNGBDBM498126(US11013745, Compound E-Y42)
Affinity DataIC50:  4.80nMAssay Description:The TR-FRET method was used to measure the PRC2 enzyme activity. First, the enzyme was mixed with compounds at different concentrations and incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent