BDBM498921 (3S,4R)-1-(N~2~- cyclohexyl- N~2~,N~6~,N~6~- trimethyl-D-lysyl)-4- {[(2-fluoro-4-methyl- phenyl)carbonyl]amino}- N-(thiophen-2- ylmethyl)piperidine-3- carboxamide::US11014920, Compound 29

SMILES CN(C)CCCC[C@@H](N(C)C1CCCCC1)C(=O)N1CC[C@@H](NC(=O)c2ccc(C)cc2F)[C@H](C1)C(=O)NCc1cccs1

InChI Key InChIKey=JAUJECFQKYOHTH-FAOMPSFFSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498921   

TargetCoagulation factor XII(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM498921((3S,4R)-1-(N~2~- cyclohexyl- N~2~,N~6~,N~6~- trime...)
Affinity DataIC50:  37.6nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent