BDBM498924 N-{(3S,4R)-1-[N~2~- cyclohexyl-N~6~- methyl-N~6~- (methylsulfonyl)-D- lysyl]-3-[(thiophen-2- ylmethyl)carbamoyl]pi- peridin-4-yl}-6- azaspiro[2.5]octane-6- carboxamide::US11014920, Compound 32

SMILES CN(CCCC[C@@H](NC1CCCCC1)C(=O)N1CC[C@@H](NC(=O)N2CCC3(CC3)CC2)[C@H](C1)C(=O)NCc1cccs1)S(C)(=O)=O

InChI Key InChIKey=FXYOMAYKWCZNPH-ZGIBFIJWSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498924   

TargetCoagulation factor XII(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM498924(N-{(3S,4R)-1-[N~2~- cyclohexyl-N~6~- methyl-N~6~- ...)
Affinity DataIC50:  22.5nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent