BDBM498928 N-((3S,4R)-1-((R)-3- cyclohexyl-2- (cyclohexylamino)pro- panoyl)-3-((thiophen- 2-ylmethyl)carbamoyl)pi- peridin-4-yl)-1-oxo-2,7- diazaspiro[4.5]decane- 7-carboxamide::US11014920, Compound 36

SMILES O=C(Nc1cccs1)[C@H]1CN(CC[C@H]1NC(=O)N1CCCC2(CCNC2=O)C1)C(=O)[C@@H](CC1CCCCC1)NC1CCCCC1

InChI Key InChIKey=ALXRTSBZYYYROZ-WZLXPCSASA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 498928   

TargetCoagulation factor XII(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM498928(N-((3S,4R)-1-((R)-3- cyclohexyl-2- (cyclohexylamin...)
Affinity DataIC50:  428nMAssay Description:Factor XIIa activity determinations were made in 50 mM HEPES buffer containing 150 mM NaCl, 5 mM CaCl2, and 0.1% PEG 8000 (polyethylene glycol; JT Ba...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent