BDBM50000714 3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-1-morpholin-4-yl-propan-1-one::3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-1-morpholin-4-yl-propan-1-one(WEB 2086)::3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-1-morpholin-4-yl-propan-1-one(WEB2086)::Apafant::CHEMBL280164::WEB2086

SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl

InChI Key InChIKey=JGPJQFOROWSRRS-UHFFFAOYSA-N

Data  5 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50000714   

TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataKi:  23.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataKi:  39.6nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataKi:  79.3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataKi:  98nMAssay Description:In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataKi:  98nMAssay Description:Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  91nMAssay Description:Concentration tested in vitro to inhibit PAF-induced maximum aggregation (PAF-Antagonistic activity) by 50%.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  91nMAssay Description:Inhibition of PAF-induced platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  94nMAssay Description:Displacement of [3H]-PAF from PAF receptor of human platelet membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  146nMAssay Description:In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  200nMAssay Description:Inhibition of [3H]-PAF binding to dog platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  50nMAssay Description:Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  200nMAssay Description:In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  40nMAssay Description:Concentration required to cause 50% inhibition of platelet activating factor (PAF)-induced platelet aggregation of human platelet rich plasma when ch...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Rhone-Poulenc Sante

Curated by PDSP Ki Database
LigandPNGBDBM50000714(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Affinity DataIC50:  200nMAssay Description:PAF-antagonist activity determined in dog platelets by PAF-binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed