BDBM50000879 7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-dihydro-imidazo[4,5-b]quinolin-2-one(HCl)::CHEMBL89679

SMILES O=c1[nH]c2cc3cc(OCCCCc4nnnn4C4CCCCC4)ccc3nc2[nH]1

InChI Key InChIKey=JAODEWCDRHAJPF-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50000879   

TargetP2Y purinoceptor 12(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000879(7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-d...)
Affinity DataEC50:  250nMAssay Description:Inhibition of platelet aggregation using Adenosine diphosphate (ADP) as activating agent in rabbit platelet rich plasma (PRP)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000879(7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-d...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50000879(7-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-1,3-d...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed