BDBM50001000 CHEBI:29133::DEXTRORPHAN::US11535596, Compound Dextorphan (DX)

SMILES [H][C@]12Cc3ccc(O)cc3[C@@]3(CCCC[C@]13[H])CCN2C

InChI Key InChIKey=JAQUASYNZVUNQP-PVAVHDDUSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50001000   

TargetSigma non-opioid intracellular receptor 1(Human)
Center For Neurologic Study

US Patent
LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataKi:  182nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetGlutamate receptor ionotropic, NMDA 1(Human)
Center For Neurologic Study

US Patent
LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataKi:  1.11E+3nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
In DepthDetails US Patent

TargetSolute carrier family 22 member 1(Human)
University Medicine Greifswald

Curated by ChEMBL
LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human OCT1 expressed in HEK293 cells assessed as reduction in ASP+ substrate uptake by microplate reader based analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1(Human)
Center For Neurologic Study

US Patent
LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataIC50:  1.53E+3nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Xavier University of Louisiana

Curated by ChEMBL
LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataIC50:  1.30E+3nMpH: 7.6Assay Description:Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Center For Neurologic Study

US Patent
LigandPNGBDBM50001000(CHEBI:29133 | DEXTRORPHAN | US11535596, Compound D...)
Affinity DataIC50:  259nMAssay Description:In vitro binding assays for the phencyclidine site of NMDA-type glutamate receptors, and for sigma-1 receptors, both of which are known to be bound b...More data for this Ligand-Target Pair
In DepthDetails US Patent