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BDBM50001561 5-(6-Imino-3-thiophen-3-yl-6H-pyridazin-1-ylmethyl)-isoxazol-3-ol; hydrate::CHEMBL132060

SMILES: N=c1ccc(nn1Cc1cc(=O)[nH]o1)-c1ccsc1

InChI Key: InChIKey=XETICWBKUKSDFH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50001561   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA receptor alpha-1 subunit


(Mus musculus)
BDBM50001561
PNG
(5-(6-Imino-3-thiophen-3-yl-6H-pyridazin-1-ylmethyl...)
Show SMILES N=c1ccc(nn1Cc1cc(=O)[nH]o1)-c1ccsc1
Show InChI InChI=1S/C12H10N4O2S/c13-11-2-1-10(8-3-4-19-7-8)14-16(11)6-9-5-12(17)15-18-9/h1-5,7,13H,6H2,(H,15,17)
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PC sid
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Similars

Article
PubMed
n/an/a 88n/an/an/an/an/an/a



Centre de Neurochimie du CNRS

Curated by ChEMBL


Assay Description
Affinity for gamma-aminobutyric-acid A receptor measured by its ability to displace [3H]gabazine antagonist from rat brain preparations.


J Med Chem 35: 4092-7 (1992)


Article DOI: 10.1021/jm00100a015
BindingDB Entry DOI: 10.7270/Q25X29J4
More data for this
Ligand-Target Pair