BDBM50001610 7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy]-8-propyl-chroman-2-carboxylic acid::7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy]-8-propyl-chroman-2-carboxylic acid (SC41930)::CGS 24115::CHEMBL14823::SC-41930

SMILES CCCc1c(OCCCOc2ccc3CCC(Oc3c2CCC)C(O)=O)ccc(C(C)=O)c1OC

InChI Key InChIKey=ZVVCSBSDFGYRCB-UHFFFAOYSA-N

Data  5 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50001610   

TargetLeukotriene B4 receptor 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataKi:  15nMAssay Description:Inhibition of specific binding of [3H]-LTB4 to LTB4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Ciba-Geigy

Curated by PDSP Ki Database
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataKi:  131nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLeukotriene B4 receptor 2(Homo sapiens (Human))
Ciba-Geigy

Curated by PDSP Ki Database
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataKi:  137nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataKi:  220nMAssay Description:Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]-LTB4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataKi:  280nMAssay Description:In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against leukotriene B4 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  20nMAssay Description:Compound was tested for inhibitory activity against LTB4 (leukotriene) bindingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  140nMAssay Description:In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced ChemotaxisMore data for this Ligand-Target Pair
In DepthDetails Article
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  300nMAssay Description:Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1/2(Homo sapiens (Human))TBA
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  200nMAssay Description:Inhibition of specific binding of [3H]LTB4 to LTB4 receptor in human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  43nMAssay Description:Binding affinity of the compound towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  300nMAssay Description:Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  300nMAssay Description:Concentration of the compound inhibiting the binding of [3H]-LTB4 to human neutrophilsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50001610(7-[3-(4-Acetyl-3-methoxy-2-propyl-phenoxy)-propoxy...)
Affinity DataIC50:  320nMAssay Description:Binding affinity for Leukotriene B4 (LTB4) receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed