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BDBM50001638 6-{6-Phenyl-4-[4-(2,2,2-trifluoro-acetylamino)-phenyl]-pyridin-2-yloxy}-hexanoic acid::CHEMBL336303

SMILES: OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(NC(=O)C(F)(F)F)cc1

InChI Key: InChIKey=DATRLPAIFYGEBS-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50001638   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001638
PNG
(6-{6-Phenyl-4-[4-(2,2,2-trifluoro-acetylamino)-phe...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(NC(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N2O4/c26-25(27,28)24(33)29-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)30-22(16-19)34-14-6-2-5-9-23(31)32/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,33)(H,31,32)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
LTB4R


(Homo sapiens (Human))
BDBM50001638
PNG
(6-{6-Phenyl-4-[4-(2,2,2-trifluoro-acetylamino)-phe...)
Show SMILES OC(=O)CCCCCOc1cc(cc(n1)-c1ccccc1)-c1ccc(NC(=O)C(F)(F)F)cc1
Show InChI InChI=1S/C25H23F3N2O4/c26-25(27,28)24(33)29-20-12-10-17(11-13-20)19-15-21(18-7-3-1-4-8-18)30-22(16-19)34-14-6-2-5-9-23(31)32/h1,3-4,7-8,10-13,15-16H,2,5-6,9,14H2,(H,29,33)(H,31,32)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair