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BDBM50001653 6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-yloxy]-hexanoic acid::CHEMBL137472

SMILES: CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1

InChI Key: InChIKey=PGYDTYLUNVVWMR-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50001653   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
LTB4R


(Homo sapiens (Human))
BDBM50001653
PNG
(6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-ylo...)
Show SMILES CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O3/c1-25-21-13-11-18(12-14-21)20-16-22(19-8-4-2-5-9-19)26-23(17-20)29-15-7-3-6-10-24(27)28/h2,4-5,8-9,11-14,16-17,25H,3,6-7,10,15H2,1H3,(H,27,28)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of LTB4-induced elastase release in human polymorphonuclear leukocytes


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001653
PNG
(6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-ylo...)
Show SMILES CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O3/c1-25-21-13-11-18(12-14-21)20-16-22(19-8-4-2-5-9-19)26-23(17-20)29-15-7-3-6-10-24(27)28/h2,4-5,8-9,11-14,16-17,25H,3,6-7,10,15H2,1H3,(H,27,28)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the human polymorphonuclear leukocytes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair
Leukotriene B4 receptor


(Homo sapiens (Human))
BDBM50001653
PNG
(6-[4-(4-Methylamino-phenyl)-6-phenyl-pyridin-2-ylo...)
Show SMILES CNc1ccc(cc1)-c1cc(OCCCCCC(O)=O)nc(c1)-c1ccccc1
Show InChI InChI=1S/C24H26N2O3/c1-25-21-13-11-18(12-14-21)20-16-22(19-8-4-2-5-9-19)26-23(17-20)29-15-7-3-6-10-24(27)28/h2,4-5,8-9,11-14,16-17,25H,3,6-7,10,15H2,1H3,(H,27,28)
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 5n/an/an/an/an/an/a



Centre de Recherche de Vitry-Alfortville

Curated by ChEMBL


Assay Description
Inhibition of [3H]-LTB4 binding to Leukotriene B4 receptor in the guinea pig spleen membranes.


J Med Chem 35: 4315-24 (1992)


Article DOI: 10.1021/jm00101a008
BindingDB Entry DOI: 10.7270/Q2QR4W2W
More data for this
Ligand-Target Pair