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BDBM50001901 1-(2-Chloro-phenyl)-piperazine::CHEMBL9841

SMILES: Clc1ccccc1N1CCNCC1

InChI Key: InChIKey=PWZDJIUQHUGFRJ-UHFFFAOYSA-N

Data: 11 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50001901   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 1B/1D receptor


(Rattus norvegicus (Rat))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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12n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 1B receptor by [3H]-5-HT displacement.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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20n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 1A receptor by [3H]-WB-4101 displacement.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Serotonin 1 (5-HT1) receptor


(RAT-Rattus norvegicus (rat)-Rattus norvegicus (Rat...)
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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24n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity in radioreceptor binding assay by using [3H]5-HT radioligand against 5-hydroxytryptamine 1 receptor


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
adrenergic Alpha2


(BOVINE)
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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25n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]-clonidine as the radioligand


J Med Chem 26: 1696-701 (1984)


Article DOI: 10.1021/jm00366a007
BindingDB Entry DOI: 10.7270/Q2251H67
More data for this
Ligand-Target Pair
Cerebral cortex alpha adrenergic receptor


(CALF)
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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160n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand


J Med Chem 26: 1696-701 (1984)


Article DOI: 10.1021/jm00366a007
BindingDB Entry DOI: 10.7270/Q2251H67
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Rattus norvegicus (rat))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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226n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity for 5-HT1A measured by displacing [3H]-8-OH-DPAT from rat cortical membranes; Not determined


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor


(Rattus norvegicus (rat)-Rattus norvegicus (Rat))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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261n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity in radioreceptor binding against Alpha-1 adrenergic receptor


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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710n/an/an/an/an/an/an/an/a



Universitá di Catania

Curated by ChEMBL


Assay Description
Binding affinity measured for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat cortical membranes


J Med Chem 34: 1850-4 (1991)


Article DOI: 10.1021/jm00110a014
BindingDB Entry DOI: 10.7270/Q25B01FV
More data for this
Ligand-Target Pair
Dopamine D2 receptor/Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity determined in radioreceptor binding assay against dopamine receptor D2


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
DOPAMINE


(RAT)
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity determined in radioreceptor binding assay by using [3H]-SCH-23,390 radioligand against dopamine receptor D1


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Serotonin 2 (5-HT2) receptor


(Rattus norvegicus (rat)-RAT-Rattus norvegicus (Rat...)
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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>1.00E+3n/an/an/an/an/an/an/an/a



McNeil Pharmaceutical and Janssen Research Foundation Worldwide

Curated by ChEMBL


Assay Description
Binding affinity at rat 5-hydroxytryptamine 2 receptor by [3H]ketanserin displacement.


J Med Chem 32: 1052-6 (1989)


Article DOI: 10.1021/jm00125a020
BindingDB Entry DOI: 10.7270/Q2HD7TNH
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Canis familiaris)
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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n/an/a 1.60E+4n/an/an/an/an/an/a



Berlex Laboratories

Curated by ChEMBL


Assay Description
Binding affinity towards Beta-2 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine lung ti...


J Med Chem 35: 743-50 (1992)


Article DOI: 10.1021/jm00082a016
BindingDB Entry DOI: 10.7270/Q2319TT0
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (human))
BDBM50001901
PNG
(1-(2-Chloro-phenyl)-piperazine | CHEMBL9841)
Show SMILES Clc1ccccc1N1CCNCC1
Show InChI InChI=1S/C10H13ClN2/c11-9-3-1-2-4-10(9)13-7-5-12-6-8-13/h1-4,12H,5-8H2
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n/an/a 1.20E+4n/an/an/an/an/an/a



Berlex Laboratories

Curated by ChEMBL


Assay Description
Binding affinity for Beta-1 adrenergic receptor by displacing [3H]dihydroalprenolol, in partially purified membrane fractions from canine ventricular...


J Med Chem 35: 743-50 (1992)


Article DOI: 10.1021/jm00082a016
BindingDB Entry DOI: 10.7270/Q2319TT0
More data for this
Ligand-Target Pair