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BDBM50002582 CHEMBL2113168

SMILES: COCCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)N3CCOCC3)c2cc1OC

InChI Key: InChIKey=ZFNKWFXFKRJHMO-UHFFFAOYSA-N

Data: 2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50002582   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50002582
PNG
(CHEMBL2113168)
Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)N3CCOCC3)c2cc1OC
Show InChI InChI=1S/C22H24N4O6/c1-29-7-8-32-21-11-15-14(9-20(21)30-2)22(24-13-23-15)25-16-10-19(28)17(12-18(16)27)26-3-5-31-6-4-26/h9-13H,3-8H2,1-2H3,(H,23,24,25)
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cells


J Med Chem 48: 7560-81 (2005)


Article DOI: 10.1021/jm050559f
BindingDB Entry DOI: 10.7270/Q2028R3S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM50002582
PNG
(CHEMBL2113168)
Show SMILES COCCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)N3CCOCC3)c2cc1OC
Show InChI InChI=1S/C22H24N4O6/c1-29-7-8-32-21-11-15-14(9-20(21)30-2)22(24-13-23-15)25-16-10-19(28)17(12-18(16)27)26-3-5-31-6-4-26/h9-13H,3-8H2,1-2H3,(H,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 101n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of poly(Glu4-Tyr)peptide phosphorylation by recombinant VEGFR2 at 10 uM ATP


J Med Chem 48: 7560-81 (2005)


Article DOI: 10.1021/jm050559f
BindingDB Entry DOI: 10.7270/Q2028R3S
More data for this
Ligand-Target Pair