BDBM50003126 4-(5-Amino-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-butyl-phenol::CHEMBL17091

SMILES CC(C)(C)c1cc(cc(c1O)C(C)(C)C)-c1nsc(N)n1

InChI Key InChIKey=HYHIPGJKSYRVCB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50003126   

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003126(4-(5-Amino-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-but...)
Affinity DataIC50: >2.00E+4nMAssay Description:IC50 value against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003126(4-(5-Amino-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-but...)
Affinity DataIC50:  2.20E+3nMAssay Description:Evaluated in vitro for its inhibitory activity against Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003126(4-(5-Amino-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-but...)
Affinity DataIC50:  330nMAssay Description:Evaluated in vitro for its inhibitory activity against 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003126(4-(5-Amino-[1,2,4]thiadiazol-3-yl)-2,6-di-tert-but...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of recombinant human prostaglandin G/H synthase 2 (COX-2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed