BDBM50003618 1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethyl}-1,2,5,6-tetrahydro-pyridine-3-carboxylic acid; hydrochloride::CHEMBL542207::CHEMBL77287

SMILES OC(=O)C1=CCCN(CCOC(c2ccc(cc2)C(F)(F)F)c2ccc(cc2)C(F)(F)F)C1

InChI Key InChIKey=CMHQDSBIBSKHFP-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50003618   

TargetSodium- and chloride-dependent GABA transporter 1(Rattus norvegicus)
Novo Nordisk

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataKi:  440nMAssay Description:In vitro inhibition of [3H]GABA uptake at the Sodium- and chloride-dependent GABA transporter 1 (GAT-1) uptake site in rat brain synaptosomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataIC50:  1.28E+6nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataIC50:  260nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataIC50:  3.33E+5nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of veratridine-stimulated [14C]- guanidine influx into rat cortical sliceMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50003618(1-{2-[Bis-(4-trifluoromethyl-phenyl)-methoxy]-ethy...)
Affinity DataIC50:  3.00E+5nMAssay Description:Inhibition of human GABA transporter (hBGT-1) activity.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed