BDBM50004633 (S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester::4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester::4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-imidazo[4,5-c]pyridin-1-yl)-phenyl]-5-(pyridin-2-ylcarbamoyl)-nicotinic acid ethyl ester::CHEMBL29067::UK-74505

SMILES CCOC(=O)C1=C(N=C(C)C(C1c1ccccc1Cl)C(=O)Nc1ccccn1)c1ccc(cc1)-n1c(C)nc2cnccc12

InChI Key InChIKey=RCODMGPJQVRMFZ-UHFFFAOYSA-N

Data  3 KI  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50004633   

TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-ligand from platelet activating factor (PAF) receptor in rabbit plateletsMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataKi:  7.10nMAssay Description:Antagonist activity against platelet activating factor (PAF) receptor in rabbit platelet membranes using [3H]C18-PAF as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataKi: >3.00E+4nMAssay Description:Displacement of [3H]-leukotriene D4 (LTD4) from receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  6.80E+3nMAssay Description:Displacement of Bodipy-labelled cyclopamine from Smo expressed in COS-1 cells in presence of 2% FBS after 4 to 6 hrs by FACS flow cytometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  4.90nMAssay Description:Inhibitory effect on PAF induced platelets aggregation in rabbitMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  13nMAssay Description:Antagonistic activity for inhibition of [3H]PAF receptor binding to washed human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  4.90nMAssay Description:Inhibitory effect on PAF induced platelets aggregation in rabbitMore data for this Ligand-Target Pair
In DepthDetails Article
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  2nMAssay Description:Inhibitory effect on PAF induced platelets aggregation in rabbitMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  6.60E+3nMAssay Description:Displacement of [3H]nitrendipine from L-type calcium channel of bovine frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  4.30nMAssay Description:In vitro inhibition of PAF-induced aggregation of rabbit washed platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  4.30nMAssay Description:In vitro antagonist activity against platelet activating factor (PAF) receptor, using washed rabbit plateletsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-activating factor receptor(Cavia porcellus)
TBA

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50:  4.30nMAssay Description:Antagonistic activity was tested against Platelet-Activating Factor-induced aggregation of rabbit washed platelets.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1D(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50004633((S)-4-(2-Chloro-phenyl)-6-methyl-2-[4-(2-methyl-im...)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]-diltiazem from L-type calcium channel of bovine frontal cortex membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed