BDBM50005865 2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[2,3-d]pyrimidin-6-ylmethyl)-amino]-benzoylamino}-4-sulfo-butyric acid::CHEMBL417696

SMILES Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCS(O)(=O)=O)C(O)=O)Cc2c(=O)[nH]1

InChI Key InChIKey=RYAKEVWNSQUJCU-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50005865   

TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...)
Affinity DataKi:  190nMAssay Description:In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFolylpolyglutamate synthase, mitochondrial(Mus musculus)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...)
Affinity DataKi:  2.20E+4nMAssay Description:In vitro inhibition of mouse liver Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...)
Affinity DataIC50:  2.10E+6nMAssay Description:In vitro inhibition of human thymidylate synthase (TS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50005865(2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibition of human dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed