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BDBM50006373 3'-butyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,2',5(3'H)-trione::CHEMBL65869

SMILES: CCCCN1C(=O)Nc2ccccc2C11NC(=O)NC1=O

InChI Key: InChIKey=AMWPEFUDEJMQIW-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006373   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006373
PNG
(3'-butyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinaz...)
Show SMILES CCCCN1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C14H16N4O3/c1-2-3-8-18-13(21)15-10-7-5-4-6-9(10)14(18)11(19)16-12(20)17-14/h4-7H,2-3,8H2,1H3,(H,15,21)(H2,16,17,19,20)
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair