BindingDB logo
myBDB logout

BDBM50006379 3'-isopropyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,2',5(3'H)-trione::CHEMBL63377

SMILES: CC(C)N1C(=O)Nc2ccccc2C11NC(=O)NC1=O

InChI Key: InChIKey=XXUBANDTWZRZKL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006379   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006379
PNG
(3'-isopropyl-1'H,2H,5H-spiro[imidazolidine-4,4'-qu...)
Show SMILES CC(C)N1C(=O)Nc2ccccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C13H14N4O3/c1-7(2)17-12(20)14-9-6-4-3-5-8(9)13(17)10(18)15-11(19)16-13/h3-7H,1-2H3,(H,14,20)(H2,15,16,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair