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BDBM50006387 3'-methyl-6',8'-dinitro-1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,2',5(3'H)-trione::CHEMBL65731

SMILES: CN1C(=O)Nc2c(cc(cc2C11NC(=O)NC1=O)[N+]([O-])=O)[N+]([O-])=O

InChI Key: InChIKey=SVMPAHFUSVWHHQ-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006387   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006387
PNG
(3'-methyl-6',8'-dinitro-1'H,2H,5H-spiro[imidazolid...)
Show SMILES CN1C(=O)Nc2c(cc(cc2C11NC(=O)NC1=O)[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C11H8N6O7/c1-15-10(20)12-7-5(11(15)8(18)13-9(19)14-11)2-4(16(21)22)3-6(7)17(23)24/h2-3H,1H3,(H,12,20)(H2,13,14,18,19)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 260n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair