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BDBM50006390 3',7'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-quinazoline]-2,2',5(3'H)-trione::CHEMBL65659

SMILES: CN1C(=O)Nc2cc(C)ccc2C11NC(=O)NC1=O

InChI Key: InChIKey=GJCWAXMKQOMPAE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50006390   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50006390
PNG
(3',7'-dimethyl-1'H,2H,5H-spiro[imidazolidine-4,4'-...)
Show SMILES CN1C(=O)Nc2cc(C)ccc2C11NC(=O)NC1=O
Show InChI InChI=1S/C12H12N4O3/c1-6-3-4-7-8(5-6)13-11(19)16(2)12(7)9(17)14-10(18)15-12/h3-5H,1-2H3,(H,13,19)(H2,14,15,17,18)
PDB

UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 220n/an/an/an/an/an/a



Tanabe Seiyaku Co., Ltd.

Curated by ChEMBL


Assay Description
Tested in vitro for inhibitory activity against partially purified aldose reductase from male rabbit lens


J Med Chem 35: 2085-94 (1992)


Article DOI: 10.1021/jm00089a021
BindingDB Entry DOI: 10.7270/Q2V123RK
More data for this
Ligand-Target Pair