BDBM50007140 1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-diol::CHEMBL419680

SMILES Oc1ccc2[C@H](CNCC=C)OC(Cc2c1O)C1CCCCC1

InChI Key InChIKey=NOOMHYKWRAKBNS-ZVAWYAOSSA-N

Data  7 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50007140   

Target5-hydroxytryptamine receptor 2C(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi:  1.26E+3nMAssay Description:Binding affinity of the compound towards 5-hydroxytryptamine 1C receptor using [125 I]-SCH23982 as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi:  1.54E+3nMAssay Description:Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi:  2.20E+3nMAssay Description:Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-1 adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity of the compound towards beta-1 adrenergic receptor using [3H]-iodocyanopindolol as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity using [3H]-spiperone radioligand competitive binding assay against dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity of the compound towards 5-hydroxytryptamine 1A receptor using [3H]8-OH-DPAT as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataKi: >2.00E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2- receptor using [3H]ketanserin as radioligand in competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration required to inhibit 50% dopamine receptor D2 in a cell free homogenate of intermediate lobe of pituitary glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataEC50:  47nMAssay Description:Concentration required to inhibit 50% dopamine receptor D1 activity using cell free homogenate of carp retinaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(RAT)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50007140(1-Allylaminomethyl-3-cyclohexyl-isochroman-5,6-dio...)
Affinity DataEC50:  30nMAssay Description:Inhibition of Dopamine receptor D1 activity by functional cyclase assay using cell free homogenate of rat striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed