BDBM50007203 CHEMBL3237875
SMILES COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)[C@@]2(C)CO2)cc1
InChI Key InChIKey=WQAVPPWWLLVGFK-VTNASVEKSA-N
Data 56 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 56 hits for monomerid = 50007203
Affinity DataIC50: 450nMAssay Description:Inhibition of beta5i subunit of immunoproteasome (unknown origin) by active-site ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of proteasome subunit beta-5i (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.70nMAssay Description:Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 460nMAssay Description:Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of proteasome subunit beta-2i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of proteasome subunit beta-5i in human RPMI8226 cells using BODIPY-NC005 by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometryMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomicin by fluorescent densitometryMore data for this Ligand-Target Pair
Affinity DataIC50: 930nMAssay Description:Inhibition of proteasome beta2 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.27E+4nMAssay Description:Inhibition of proteasome beta1 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 911nMAssay Description:Inhibition of MECL1 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 422nMAssay Description:Inhibition of proteasome beta5 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of LMP2 in human MOLT4 cell lysate after 1 hr by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of human 20S constitutive proteasome beta-5 using Suc-LLVY-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence ass...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of human 20S constitutive proteasome beta-1 using Z-LLE-betaNA as substrate incubated for 15 mins measured for 45 mins by fluorescence ass...More data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 4.85E+3nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of human 20S immunoproteasome beta-5 using Suc-LLVY-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibition of human 20S constitutive proteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of human 20S immunoproteasome beta-1 using Ac-PAL-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 422nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 287nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.27E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 927nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of LMP7 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 401nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 913nMAssay Description:Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 287nMAssay Description:Inhibition of LMP2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 328nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 39nMAssay Description:Inhibition of LMP7 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 927nMAssay Description:Inhibition of 20S proteosome beta 2 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 902nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 422nMAssay Description:Inhibition of 20S proteosome beta 5 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 401nMAssay Description:Inhibition of 20S proteosome beta 5 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-10(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 902nMAssay Description:Inhibition of MECL1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 328nMAssay Description:Inhibition of LMP2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >1.27E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in human MOLT4 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 699nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 913nMAssay Description:Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of 20S proteosome beta 1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 699nMAssay Description:Inhibition of MECL1 in mouse A20 cells by ELISAMore data for this Ligand-Target Pair
TargetProteasome subunit beta type-9(Homo sapiens (Human))
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Leiden Institute Of Chemistry And Netherlands Proteomics Centre
Curated by ChEMBL
Affinity DataIC50: 1.01E+3nMAssay Description:Inhibition of LMP2 in human 20S immunoproteasome using Ac-PAL-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Beta1 subunit in human 20S proteasome using Ac-nLPnLD-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of LMP7 in human 20S immunoproteasome using Ac-ANW-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 473nMAssay Description:Inhibition of Beta5 in human 20S immunoproteasome usingAc-WLA-AMC as substrate after 1 hr by fluorescence based microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of 20S immunoproteasome beta 5 chymotrypsin-like activity in human H226 cell using Suc-LLVY-AMC as substrate for 10 mins by fluorescence b...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of human proteasome subunit beta-5i chymotrypsin like activity using SUC-ANW-AMC as flurogenic substrate preincubated for 15 mins followed...More data for this Ligand-Target Pair