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BDBM50007305 CHEMBL319983::Sodium; 6-{4-chloro-2-[3-(4-fluoro-phenoxy)-propyl]-6-methyl-phenoxy}-3,5-dihydroxy-hexanoate

SMILES: Cc1cc(Cl)cc(CCCOc2ccc(F)cc2)c1OCC(O)C[C@@H](O)CC([O-])=O

InChI Key: InChIKey=HOJUELIUZSUFTD-MRTLOADZSA-M

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50007305   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))
BDBM50007305
PNG
(CHEMBL319983 | Sodium; 6-{4-chloro-2-[3-(4-fluoro-...)
Show SMILES Cc1cc(Cl)cc(CCCOc2ccc(F)cc2)c1OCC(O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C22H26ClFO6/c1-14-9-16(23)10-15(3-2-8-29-20-6-4-17(24)5-7-20)22(14)30-13-19(26)11-18(25)12-21(27)28/h4-7,9-10,18-19,25-26H,2-3,8,11-13H2,1H3,(H,27,28)/p-1/t18-,19?/m1/s1
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MMDB

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Similars

Article
PubMed
n/an/a 80n/an/an/an/an/an/a



Hoechst AG

Curated by ChEMBL


Assay Description
In vitro inhibition of HMG-CoA reductase in solubilized rat liver.


J Med Chem 34: 2962-83 (1991)


Article DOI: 10.1021/jm00114a004
BindingDB Entry DOI: 10.7270/Q2C829WX
More data for this
Ligand-Target Pair