BDBM50007407 1-NP::1-Naphthalen-1-yl-piperazine::4-Naphthalen-1-yl-piperazin-1-ium::CHEMBL277120

SMILES C1CN(CCN1)c1cccc2ccccc12

InChI Key InChIKey=VNICFCQJUVFULD-UHFFFAOYSA-N

Data  45 KI  2 IC50  1 Kd  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 50 hits for monomerid = 50007407   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  0.890nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  3.72nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  5nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1 receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  5.24nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  6.20nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1D receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  6.20nMAssay Description:Binding affinity of the compound was evaluated at human recombinant 5-hydroxytryptamine 1D receptor using [3H]-5-CT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  7.41nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  9.20nMAssay Description:Binding affinity of the compound was evaluated at human recombinant 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  9.20nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1A receptor in HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  10nMAssay Description:Receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptor in Cos-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  11nMAssay Description:Binding affinity of the compound was evaluated at human recombinant 5-hydroxytryptamine 1B receptor using [3H]-5-CT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  11nMAssay Description:Binding affinity of a compound to rat brain 5-hydroxytryptamine 1A (serotonin) receptor assayed by radiolabeled [3H]-8-OH-DPAT ligand displacementMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  11nMAssay Description:Evaluated for binding affinity towards 5-hydroxytryptamine 1A receptor in rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  12.0nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine 1D receptor(Bos taurus (Bovine))
Synaptic Pharmaceutical

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  15nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Universit£

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-2-(di-N-propylamino)-8-hydroxytetralin from central 5-hydroxytryptamine 1A receptor recognition sites in rat frontal cortex homo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
State University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  18nMAssay Description:Binding affinity at rat 5-hydroxytryptamine 7 receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  18nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortical membrane homogenatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  18nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2 receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
State University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  18.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
State University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  18.3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
State University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  33.9nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  39.8nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(MOUSE)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  40nMAssay Description:Binding affinity towards mouse 5-hydroxytryptamine 5A receptor was evaluated using [3H]- LSD as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  40nMAssay Description:Binding affinity for rodent 5-hydroxytryptamine 5A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
State University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  53.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1F(Homo sapiens (Human))
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  53.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  67.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]5-HT from human 5-hydroxytryptamine 7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  83nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 7(Rattus norvegicus (rat))
State University Of Groningen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]LSD from rat rat kidney proximal convoluted tubule 5HT7R expressed in COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  83.2nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  100nMAssay Description:Binding affinity against 5-hydroxytryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  104nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 6 receptor was evaluated using [125I]-2-iodo LSD as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  104nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
Target5-hydroxytryptamine receptor 6(RAT)
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  105nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A(RAT)
Virginia Commonwealth University

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  110nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  120nMAssay Description:Binding affinity against 5-hydroxy tryptamine 6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 3A/3B/3C/3D/3E(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  175nMAssay Description:Compound was tested for the inhibition of [3H]-GR-65,630 binding to 5-hydroxytryptamine 3 receptor expressed in NG 108-15 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1E(Homo sapiens (Human))
University Of Alberta

Curated by PDSP Ki Database
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  209nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  2.72E+3nMAssay Description:Binding affinity of the compound towards sigma receptor in guinea pig brain membranes using [3H]-DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil cytosol factor 1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKi:  1.52E+6nMAssay Description:Covalent inhibition of recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cells intera...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil cytosol factor 1(Homo sapiens)
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataKd:  3.66E+5nMAssay Description:Binding affinity to immobilized recombinant human His-tagged p47phox SH3A-B domain (151 to 285 residues) expressed in Escherichia coli BL21 (DE3) cel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataEC50: >1.00E+4nMAssay Description:Binding affinity of the compound was evaluated at human recombinant 5-hydroxytryptamine 1B receptor using [3H]-5-CT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataIC50:  62nMAssay Description:Inhibitory concentration against 5-hydroxytryptamine 2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition constant against dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Centre De Recherche Pierre Fabre

Curated by ChEMBL
LigandPNGBDBM50007407(1-NP | 1-Naphthalen-1-yl-piperazine | 4-Naphthalen...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at 5-hydroxytryptamine 1B receptor by measuring the inhibition of forskolin-stimulated cAMP formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed