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BDBM50007772 CHEMBL3233782

SMILES: OC1CN(C\C=C\C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3s2)C1

InChI Key: InChIKey=JKABMGXBBVXKDI-OWOJBTEDSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50007772   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50007772
PNG
(CHEMBL3233782)
Show SMILES OC1CN(C\C=C\C(=O)Nc2cc3c(Nc4ccc(F)c(Cl)c4)ncnc3s2)C1
Show InChI InChI=1S/C19H17ClFN5O2S/c20-14-6-11(3-4-15(14)21)24-18-13-7-17(29-19(13)23-10-22-18)25-16(28)2-1-5-26-8-12(27)9-26/h1-4,6-7,10,12,27H,5,8-9H2,(H,25,28)(H,22,23,24)/b2-1+
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Similars

Article
PubMed
n/an/a 38n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of wild type EGFR domain (unknown origin) expressed in baculovirus expression system using Poly(Glu:Tyr)4:1 substrate after 60 mins by ELI...


Bioorg Med Chem 22: 2366-78 (2014)


Article DOI: 10.1016/j.bmc.2014.01.035
BindingDB Entry DOI: 10.7270/Q2QC051F
More data for this
Ligand-Target Pair