BDBM50008950 3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydro-furan-2-one::3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydro-furan-2-one(KME-4)::3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-dihydro-furan-2-one::CHEMBL8562

SMILES CC(C)(C)c1cc(\C=C2/CCOC2=O)cc(c1O)C(C)(C)C

InChI Key InChIKey=DFPYHQJPGCODSB-UKTHLTGXSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50008950   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  690nMAssay Description:Evaluated for inhibition of the formation and release of 5-lipoxygenase in isolated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  600nMAssay Description:Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human neutrophil 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  150nMAssay Description:Inhibitory activity against cyclooxygenase in rat basophilic leukemia cells using prostaglandin G/H synthase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Tested for inhibition of 5-LO by measuring the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  5.00E+3nMAssay Description:Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human platelet Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed