BDBM50008950 3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydro-furan-2-one::3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydro-furan-2-one(KME-4)::3-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(E)-ylidene]-dihydro-furan-2-one::CHEMBL8562
SMILES CC(C)(C)c1cc(\C=C2/CCOC2=O)cc(c1O)C(C)(C)C
InChI Key InChIKey=DFPYHQJPGCODSB-UKTHLTGXSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50008950
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 690nMAssay Description:Evaluated for inhibition of the formation and release of 5-lipoxygenase in isolated guinea pig ileumMore data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human neutrophil 5-lipoxygenaseMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against cyclooxygenase in rat basophilic leukemia cells using prostaglandin G/H synthase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Tested for inhibition of 5-LO by measuring the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)More data for this Ligand-Target Pair
Affinity DataIC50: 600nMAssay Description:In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1/2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human platelet Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187More data for this Ligand-Target Pair