BDBM50009075 CHEMBL22033::ICI 198615::ICI-198615::[1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-5-yl]-carbamic acid cyclopentyl ester::[1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester::[1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester (ICI 198,615)::[1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester(ICI 198, 615)::[1-(4-Benzenesulfonylaminocarbonyl-2-methoxy-benzyl)-1H-indazol-6-yl]-carbamic acid cyclopentyl ester(ICI 198615)

SMILES COc1cc(ccc1Cn1ncc2ccc(NC(=O)OC3CCCC3)cc12)C(=O)NS(=O)(=O)c1ccccc1

InChI Key InChIKey=YRCPIXCRSAKRGM-UHFFFAOYSA-N

Data  5 KI  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50009075   

TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKi:  0.200nMAssay Description:In vitro binding affinity against cysteinyl leukotriene D4 receptor from guinea pig lung membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKi:  0.240nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKi:  0.300nMAssay Description:Compound was evaluated for its ability to displace [3H]-LTD4 from LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKi:  0.300nMAssay Description:Binding affinity against LTD4 receptor in guinea pig lung membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 2(GUINEA PIG)
Pfizer

Curated by PDSP Ki Database
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKi:  6.89nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataKd:  3.01E+4nMAssay Description:Dissociation constant for CysLT1 receptor was determined by the displacement of [3H]LTD4 from guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50009075(CHEMBL22033 | ICI 198615 | ICI-198615 | [1-(4-Benz...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity to block binding of [3H]leukotriene D4 to LTD4 receptor sites in homogenized guinea pig lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed