BindingDB logo
myBDB logout

BDBM50009848 4-Hydroxy-5-oxo-1-(1-phenyl-ethyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester::CHEMBL269089

SMILES: CCOC(=O)C1CN([C@H](C)c2ccccc2)C(=O)C1=O

InChI Key: InChIKey=AZJJHUVCKBUFKA-RWANSRKNSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50009848   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50009848
PNG
(4-Hydroxy-5-oxo-1-(1-phenyl-ethyl)-2,5-dihydro-1H-...)
Show SMILES CCOC(=O)C1CN([C@H](C)c2ccccc2)C(=O)C1=O
Show InChI InChI=1S/C15H17NO4/c1-3-20-15(19)12-9-16(14(18)13(12)17)10(2)11-7-5-4-6-8-11/h4-8,10,12H,3,9H2,1-2H3/t10-,12?/m1/s1
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 840n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human placental aldose reductase.


J Med Chem 34: 1011-8 (1991)

Checked by Author
Article DOI: 10.1021/jm00107a020
BindingDB Entry DOI: 10.7270/Q2NK3FMZ
More data for this
Ligand-Target Pair