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BDBM50009850 4-Hydroxy-5-oxo-1-phenethyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester::CHEMBL7461

SMILES: CCOC(=O)C1CN(CCc2ccccc2)C(=O)C1=O

InChI Key: InChIKey=GEAVJBAVJBPHQE-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50009850   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))
BDBM50009850
PNG
(4-Hydroxy-5-oxo-1-phenethyl-2,5-dihydro-1H-pyrrole...)
Show SMILES CCOC(=O)C1CN(CCc2ccccc2)C(=O)C1=O
Show InChI InChI=1S/C15H17NO4/c1-2-20-15(19)12-10-16(14(18)13(12)17)9-8-11-6-4-3-5-7-11/h3-7,12H,2,8-10H2,1H3
PDB

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
In vitro inhibition of human placental aldose reductase.


J Med Chem 34: 1011-8 (1991)

Checked by Author
Article DOI: 10.1021/jm00107a020
BindingDB Entry DOI: 10.7270/Q2NK3FMZ
More data for this
Ligand-Target Pair