BDBM50009854 CHEMBL13078::[1-(2-Morpholin-4-yl-ethyl)-1H-indol-3-yl]-naphthalen-1-yl-methanone

SMILES O=C(c1cn(CCN2CCOCC2)c2ccccc12)c1cccc2ccccc12

InChI Key InChIKey=SZWYXJHTNGJPKU-UHFFFAOYSA-N

Data  4 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50009854   

TargetCannabinoid receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  82nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  2.09E+7nMAssay Description:Displacement of [3H]CP-55940 from Cannabinoid receptor 1 of rat forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  1.66E+8nMAssay Description:Binding affinity at cannabinoid receptor 1 using rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataKi:  1.66E+8nMAssay Description:Cannabinoid receptor 1 binding affinity by measuring its ability to displace [3H]WIN-55212-2 in rat forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))TBA
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50:  7.80nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2 (KDR)More data for this Ligand-Target Pair
In DepthDetails
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50:  46nMAssay Description:Binding affinity against brain cannabinoid receptor 1 using [3H]-CP-55,940 as radioligand at 0.25 nM concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenylate cyclase type 5(Rattus norvegicus)
National Institute Of Diabetes And Digestive And Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataEC50:  275nMAssay Description:Compound was evaluated for inhibition of hormone stimulated Adenylate cyclase activity in N18TG2 membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Sanofi Research Division

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50:  7.80nMAssay Description:Concentration of compound required to inhibit 50% of [3H]-WIN- 55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin-H2 D-isomerase(Mus musculus)
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50009854(CHEMBL13078 | [1-(2-Morpholin-4-yl-ethyl)-1H-indol...)
Affinity DataIC50:  6nMAssay Description:Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed