BDBM50010101 2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarboxylate::Bentyl::Bicyclohexyl-1-carboxylic acid 2-diethylamino-ethyl ester::CHEMBL1123::DICYCLOMINE::Dicycloverin

SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1

InChI Key InChIKey=CURUTKGFNZGFSE-UHFFFAOYSA-N

Data  9 KI  2 IC50

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50010101   

TargetMuscarinic acetylcholine receptor M1(RAT)
Glaxo Group Research Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  0.620nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor(RABBIT)
Glaxo Group Research Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  1.51nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
Glaxo Group Research Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  1.78nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Glaxo Group Research Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]pirenzepine from muscarinic acetylcholine receptor M1 in rat cortex homogenatesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute of Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  5.10nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M4(Chick)
Glaxo Group Research Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  5.5nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute of Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  32.4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
National Institute of Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  47nMAssay Description:Displacement of [3H](-)-quinuclidinyl benzilate(QNB) from muscarinic (M2) receptor in rat heart homogenatesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute of Mental Health

Curated by PDSP Ki Database
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataKi:  244nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50010101(2-(diethylamino)ethyl 1-cyclohexylcyclohexanecarbo...)
Show SMILES CCN(CC)CCOC(=O)C1(CCCCC1)C1CCCCC1
Show InChI InChI=1S/C19H35NO2/c1-3-20(4-2)15-16-22-18(21)19(13-9-6-10-14-19)17-11-7-5-8-12-17/h17H,3-16H2,1-2H3
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair