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BDBM50010873 1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-ethyl]-cyclohexanol (HCl)::CHEMBL99503

SMILES: COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1

InChI Key: InChIKey=CDSKYZNOPRUMAE-UHFFFAOYSA-N

Data: 3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010873   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Norepinephrine Monoamine transporters


(Rattus norvegicus)
BDBM50010873
PNG
(1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-et...)
Show SMILES COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H26BrNO2/c1-19(2)12-14(17(20)9-5-4-6-10-17)13-7-8-16(21-3)15(18)11-13/h7-8,11,14,20H,4-6,9-10,12H2,1-3H3
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Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Sodium-dependent serotonin transporter


(Rattus norvegicus (rat))
BDBM50010873
PNG
(1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-et...)
Show SMILES COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H26BrNO2/c1-19(2)12-14(17(20)9-5-4-6-10-17)13-7-8-16(21-3)15(18)11-13/h7-8,11,14,20H,4-6,9-10,12H2,1-3H3
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 200n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(Rattus norvegicus (Rat))
BDBM50010873
PNG
(1-[1-(3-Bromo-4-methoxy-phenyl)-2-dimethylamino-et...)
Show SMILES COc1ccc(cc1Br)C(CN(C)C)C1(O)CCCCC1
Show InChI InChI=1S/C17H26BrNO2/c1-19(2)12-14(17(20)9-5-4-6-10-17)13-7-8-16(21-3)15(18)11-13/h7-8,11,14,20H,4-6,9-10,12H2,1-3H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 190n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain


J Med Chem 33: 2899-905 (1990)


Article DOI: 10.1021/jm00172a035
BindingDB Entry DOI: 10.7270/Q20C4WCM
More data for this
Ligand-Target Pair