BDBM50010932 (10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid::2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid::2-{4-[2-(2,4-Diamino-pteridin-6-yl)-ethyl]-benzoylamino}-pentanedioic acid(10-DAM)::CHEMBL11191

SMILES Nc1nc(N)c2nc(CCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cnc2n1

InChI Key InChIKey=LGFLRHWJJKLPCC-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50010932   

TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  0.00210nMAssay Description:Tested for inhibition of dihydrofolate reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  0.00340nMAssay Description:Concentration of the compound inhibiting dihydrofolate reductase derived from L1210 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  0.00400nMAssay Description:Inhibition of Dihydrofolate reductase (DHFR) enzyme derived from L1210 cells expressed as Ki (pM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Mus musculus (Mouse))
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataKi:  1.20E+3nMAssay Description:Binding affinity of the compound towards Dihydrofolate reductase derived from L1210 cells using [3H]- MTX as the radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
TBA

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataIC50:  4nMAssay Description:Concentration of the compound required to inhibit L. casei derived Dihydrofolate reductase activity by 50%More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of South Alabama

Curated by ChEMBL
LigandPNGBDBM50010932((10-DA, 10-Deazaminopterin)2-{4-[2-(2,4-Diamino-pt...)
Affinity DataIC50:  4.10nMAssay Description:Compound was tested for its inhibitory activity on Recombinant Human Dihydrofolate Reductase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed