BDBM50011360 CHEMBL3260990

SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N

InChI Key InChIKey=DXEATJQGQHDURZ-DEDYPNTBSA-N

Data  15 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50011360   

TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  7.00E+3nMAssay Description:Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataKd:  230nMAssay Description:Displacement of dansylated arginine from human serum albumin by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Mus musculus)
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  8.90E+3nMAssay Description:Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  1.08E+4nMAssay Description:Antagonist activity at EPAC1 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  4.40E+3nMAssay Description:Antagonist activity at EPAC2 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  9.00E+3nMAssay Description:Displacement of 8-NBD-cAMP from EPAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  1.08E+4nMAssay Description:Antagonist activity at human recombinant EPAC1 assessed as inhibition of Rap1b-bGDP exchange activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of recombinant C-terminal FLAG/HA-tagged EPAC1 (unknown origin) expressed in retrovirus infected human HeLaS3 cells assessed as reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of recombinant C-terminal FLAG/HA-tagged EPAC2 (unknown origin) expressed in retrovirus infected human HeLaS3 cells assessed as reduction ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  1.08E+4nMAssay Description:Antagonist activity at recombinant human full length EPAC1 assessed as inhibition of EPAC1-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Mus musculus)
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  4.40E+3nMAssay Description:In vito concentration required to displace [3H]cyclofoxy (Kd = 0.8 nM and concentration is 1.3 nM) from mu and kappa2 receptor in rat brain membranes...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  9.10E+3nMAssay Description:Antagonist activity at recombinant full length EPAC1 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  4.40E+3nMAssay Description:Antagonist activity at recombinant full length EPAC2 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of EPAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of EPAC2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataKd:  2.00E+4nMAssay Description:Inhibition of 8-NBD-cAMP binding to human EPAC1 cAMP binding domain (149 to 318 residues) by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlbumin(Homo sapiens (Human))
University Health Network

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataKd:  99nMAssay Description:Displacement of dansylated phenylalanine from human serum albumin by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataKd:  2.00E+4nMAssay Description:Binding affinity to human EPAC1 cAMP binding domain (149 to 318 residues) using aggregate form of compound by [15N-1H]HSQC spectroscopic analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
University Of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50011360(CHEMBL3260990)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of EPAC1 (unknown origin) assessed as cAMP-mediated GEF activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed