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BDBM50011855 4-(2-Chloro-phenyl)-9-methyl-2-naphthalen-1-ylethynyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene::CHEMBL32110

SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1cccc2ccccc12)c1ccccc1Cl

InChI Key: InChIKey=NUMYQTWXWLMVCX-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011855   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011855
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-naphthalen-1-ylethy...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1cccc2ccccc12)c1ccccc1Cl
Show InChI InChI=1S/C27H17ClN4S/c1-17-30-31-25-16-29-26(22-11-4-5-12-24(22)28)23-15-20(33-27(23)32(17)25)14-13-19-9-6-8-18-7-2-3-10-21(18)19/h2-12,15H,16H2,1H3
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Article
PubMed
n/an/a 150n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair