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BDBM50011861 4-(2-Chloro-phenyl)-9-methyl-2-(5-pyridin-2-yl-thiophen-2-ylethynyl)-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene::CHEMBL284079

SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccc(s1)-c1ccccn1)c1ccccc1Cl

InChI Key: InChIKey=YABUSIXMDKQDQO-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011861   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011861
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-(5-pyridin-2-yl-thi...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccc(s1)-c1ccccn1)c1ccccc1Cl
Show InChI InChI=1S/C26H16ClN5S2/c1-16-30-31-24-15-29-25(19-6-2-3-7-21(19)27)20-14-18(34-26(20)32(16)24)10-9-17-11-12-23(33-17)22-8-4-5-13-28-22/h2-8,11-14H,15H2,1H3
PDB

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PC sid
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Similars

Article
PubMed
n/an/a 60n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair