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BDBM50011878 4-(2-Chloro-phenyl)-9-methyl-2-phenylethynyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene::CHEMBL288098

SMILES: Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccccc1)c1ccccc1Cl

InChI Key: InChIKey=UNQJUDRRVSTPAF-UHFFFAOYSA-N

Data: 1 IC50

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011878   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011878
PNG
(4-(2-Chloro-phenyl)-9-methyl-2-phenylethynyl-6H-1-...)
Show SMILES Cc1nnc2CN=C(c3cc(sc3-n12)C#Cc1ccccc1)c1ccccc1Cl
Show InChI InChI=1S/C23H15ClN4S/c1-15-26-27-21-14-25-22(18-9-5-6-10-20(18)24)19-13-17(29-23(19)28(15)21)12-11-16-7-3-2-4-8-16/h2-10,13H,14H2,1H3
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Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
Compound tested in vitro for Platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair