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BDBM50011881 3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-2-yl]-1-morpholin-4-yl-propenone::CHEMBL286557

SMILES: Cc1nnc2CN=C(c3cc(\C=C/C(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl

InChI Key: InChIKey=XXYRUVMJEYVQRW-SREVYHEPSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011881   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet activating factor receptor


(Homo sapiens (Human))
BDBM50011881
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(\C=C/C(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl
Show InChI InChI=1S/C22H20ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-7,12H,8-11,13H2,1H3/b7-6-
PDB

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PC sid
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Similars

Article
PubMed
n/an/a 180n/an/an/an/an/an/a



Roche Research Center

Curated by ChEMBL


Assay Description
In vitro for platelet activating factor receptor antagonist activity in a binding assay using washed whole dog platelets.


J Med Chem 34: 1440-6 (1991)


Article DOI: 10.1021/jm00108a031
BindingDB Entry DOI: 10.7270/Q2BG2MZ9
More data for this
Ligand-Target Pair