BDBM50012956 1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxamido)ethyl)phenylsulfonyl)urea::1-cyclohexyl-3-[[p-[2-(5-methylpyrazinecarboxamido)ethyl]phenyl]sulfonyl]urea::CHEMBL1073::CP-28720::GLIPIZIDE::Glucotrol::Glucotrol xl::K-4024::US20230348371, Compound Glipizide

SMILES Cc1cnc(cn1)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1

InChI Key InChIKey=ZJJXGWJIGJFDTL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50012956   

TargetCytochrome P450 3A4(Human)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50:  7.45E+3nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSurfeit locus protein 1(Human)
Shanghai Senhui Medicine

US Patent
LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50:  230nMAssay Description:Procedures:a) 100 μL of reaction buffer was added to each well of a 96-well deep-well plate.b) 5 μL of diluted test compound (1% DMSO) was ...More data for this Ligand-Target Pair
In DepthDetails US Patent

LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50012956(1-cyclohexyl-3-(4-(2-(2-methylpyrazine-5-carboxami...)
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed