BDBM50013192 CHEMBL140495::[5-(2-Fluoro-phenyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethyl]-carbamic acid benzyl ester

SMILES Fc1ccccc1C1=NC(CNC(=O)OCc2ccccc2)CNc2ccccc12

InChI Key InChIKey=AHHXPJAEVZEJBL-UHFFFAOYSA-N

Data  3 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50013192   

LigandPNGBDBM50013192(CHEMBL140495 | [5-(2-Fluoro-phenyl)-2,3-dihydro-1H...)
Show SMILES Fc1ccccc1C1=NC(CNC(=O)OCc2ccccc2)CNc2ccccc12
Show InChI InChI=1S/C24H22FN3O2/c25-21-12-6-4-10-19(21)23-20-11-5-7-13-22(20)26-14-18(28-23)15-27-24(29)30-16-17-8-2-1-3-9-17/h1-13,18,26H,14-16H2,(H,27,29)
Affinity DataIC50: 91nMAssay Description:Evaluated for its concentration required for displacement of [3H]-Naloxone from opioid receptors in rat brain tissuesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50013192(CHEMBL140495 | [5-(2-Fluoro-phenyl)-2,3-dihydro-1H...)
Show SMILES Fc1ccccc1C1=NC(CNC(=O)OCc2ccccc2)CNc2ccccc12
Show InChI InChI=1S/C24H22FN3O2/c25-21-12-6-4-10-19(21)23-20-11-5-7-13-22(20)26-14-18(28-23)15-27-24(29)30-16-17-8-2-1-3-9-17/h1-13,18,26H,14-16H2,(H,27,29)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of binding of [125I]-CCK-8 to Cholecystokinin type B receptor in guinea pig brain tissuesMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A(RAT)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50013192(CHEMBL140495 | [5-(2-Fluoro-phenyl)-2,3-dihydro-1H...)
Show SMILES Fc1ccccc1C1=NC(CNC(=O)OCc2ccccc2)CNc2ccccc12
Show InChI InChI=1S/C24H22FN3O2/c25-21-12-6-4-10-19(21)23-20-11-5-7-13-22(20)26-14-18(28-23)15-27-24(29)30-16-17-8-2-1-3-9-17/h1-13,18,26H,14-16H2,(H,27,29)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of binding of [125I]-CCK-8 to Cholecystokinin type A receptor in rat pancreasMore data for this Ligand-Target Pair