BDBM50004656 (2-Carbamoyloxy-ethyl)-trimethyl-ammonium::(2-Carbamoyloxyethyl)trimethylammonium chloride::(2-Hydroxyethyl)trimethyl ammonium chloride carbamate::(2-Hydroxyethyl)trimethylammonium chloride carbamate::(carbachol)(2-Carbamoyloxy-ethyl)-trimethyl-ammonium::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride::2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride::2-(carbamoyloxy)-N,N,N-trimethylethanaminium::2-(carbamoyloxy)-N,N,N-trimethylethanaminium chloride::CARBACHOL::CARBASTAT::CHEMBL14::Carbachol chloride::Carbamylcholine::Choline carbamate chloride::Choline chloride, carbamate::Choline chlorine carbamate::Karbachol::Karbamoylcholin chlorid::MIOSTAT

SMILES C[N+](C)(C)CCOC(N)=O

InChI Key InChIKey=VPJXQGSRWJZDOB-UHFFFAOYSA-O

Data  163 KI  40 IC50  3 Kd  71 EC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 277 hits for monomerid = 50004656   

TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  4nMAssay Description:Binding activity to the muscarinic acetylcholine receptor in rat cortex, assayed using [3H]CD as a radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Medical Research Division of American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  4nMAssay Description:Binding affinity at [3H]CD radiolabeled muscarinic M2 receptor in rat cortex.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Medical Research Division of American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Mus musculus)
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  8nMAssay Description:Ability of the compound to displace [3H]-oxotremorine ([3H]-OXO-M) from mouse cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  8nMAssay Description:Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Mus musculus (mouse))
University of South Carolina

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  8nMAssay Description:Compound was evaluated for the binding affinity by displacing [3H]oxotremorine from mouse cerebral cortex tissue.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  9nMAssay Description:Binding affinity against Muscarinic acetylcholine receptor using [3H]-OXO-M as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]- Oxo-M binding to muscarinic acetylcholine receptor of rat heart membrane preparation.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(RAT)
American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]OXO-M binding against muscarinic acetylcholine receptor in rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  20nMAssay Description:Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  20nMAssay Description:Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine rece...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(RAT)
Medical Research Division of American Cyanamid Company

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  20nMAssay Description:Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Mus musculus)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  20nMAssay Description:Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  24nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  24nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  29nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  31nMAssay Description:Inhibition of binding of [3H]oxotremorine M to Muscarinic acetylcholine receptor M1 in rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  31nMAssay Description:Affinity versus [3H]oxotremorine M (agonist) binding to Muscarinic acetylcholine receptor M1 in Rat Cerebral Cortical Membranes, (Kd=0.75 nM)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Mus musculus)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  37nMAssay Description:Binding affinity of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-SMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  38nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept Inc

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  66.4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  68.2nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  73nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  100nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Homo sapiens (Human))
Abbott Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  150nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPromotilin(RABBIT)
University of Melbourne

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  158nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
University of Arizona

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  170nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  210nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha3-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  260nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  325nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  331nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  428nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  460nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rattus norvegicus (Rat))
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  590nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta2 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept Inc

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  590nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  600nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  640nMAssay Description:In vitro binding affinity for muscarinic M1 receptor by displacing [3H]-Pirenzepine binding on rat brain homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  671nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  700nMAssay Description:Displacement of [3H]NMS from rat M3'(3C)-Xa receptor F92C/F550C mutant expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Mus musculus)
The University of Toledo

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  739nMAssay Description:Binding affinity (high) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Universit£ di Milano

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  750nMAssay Description:Binding affinity to alpha4beta2 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  750nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinic acetylcholine receptor(RAT)
National Institute on Drug Abuse

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  838nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-2(Rattus norvegicus (Rat))
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  930nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  990nMAssay Description:Displacement of [3H]NMS from rat M3'(3C)-Xa receptor F92C/R551C mutant expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.04E+3nMAssay Description:Displacement of [3H]NMS from rat M3'(3C)-Xa receptor F92C/T549C mutant expressed in african green monkey COS7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3(Rattus norvegicus (Rat))
Georgetown University

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4(Rattus norvegicus (Rat))
Targacept Inc

Curated by PDSP Ki Database
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.10E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
Georgetown University School of Medicine

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.10E+3nMAssay Description:Binding affinity towards rat Nicotinic acetylcholine receptor alpha4-beta4 expressed in HEK293 cells using [3H]EB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL
LigandPNGBDBM50004656((2-Carbamoyloxy-ethyl)-trimethyl-ammonium | (2-Car...)
Affinity DataKi:  1.23E+3nMAssay Description:Displacement of [3H]NMS from human cloned muscarinic M2 receptor expressed in CHO cellsChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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