BDBM50014837 (E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyrimidin-5-yl]-vinyl}-4-hydroxy-tetrahydro-pyran-2-one::CHEMBL2368190

SMILES CC(C)c1nc(C(C)C)c(\C=C\[C@@H]2C[C@@H](O)CC(=O)O2)c(n1)-c1ccc(F)cc1

InChI Key InChIKey=UTOIEVWJKDLJGE-AQRBRUGDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50014837   

Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Homo sapiens (Human))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50014837((E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyri...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of cellular HMG-CoA reductase in cultures of human HEP G2 cells, determined by decreased incorporation of sodium [14C]-acetate into choles...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3-hydroxy-3-methylglutaryl-coenzyme A reductase(Rattus norvegicus (rat))
Hoechst

Curated by ChEMBL
LigandPNGBDBM50014837((E)-6-{2-[4-(4-Fluoro-phenyl)-2,6-diisopropyl-pyri...)
Affinity DataIC50:  4.80nMAssay Description:In vitro inhibition of rat liver HMG-CoA reductaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed