BDBM50016799 (1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol-1-yl)-acetic acid::2-(1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic acid::AY-24236::CHEMBL622::ETODOLAC::Etodolic Acid::Lodine::Lodine xl

SMILES CCc1cccc2c3CCOC(CC)(CC(O)=O)c3[nH]c12

InChI Key InChIKey=NNYBQONXHNTVIJ-UHFFFAOYSA-N

Data  10 KI  3 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50016799   

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  940nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  1.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  2.20E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  2.47E+3nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  3.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank

TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  9.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Rattus norvegicus)
University Of California

Curated by ChEMBL
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of rat Oat1 expressed in pig LLC-PK11 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Tennessee

Curated by ChEMBL
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataKi:  1.80E+6nMAssay Description:Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataIC50:  1.03E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as inhibition of LPS-stimulated PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
St. Bartholomew'S And The Royal London School Of Medicine And Dentistry

Curated by PDSP Ki Database
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of COX2 in human whole blood assessed as inhibition of TXB2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Gilead Sciences

Curated by ChEMBL
LigandPNGBDBM50016799((1,8-Diethyl-1,3,4,9-tetrahydro-pyrano[3,4-b]indol...)
Affinity DataIC50:  5.00E+4nMAssay Description:TP_TRANSPORTER: inhibition of Adefovir uptake in OAT1-expressing CHO cellsMore data for this Ligand-Target Pair
In DepthDetails PubMedDrugBank